Summary: Budesonide is a glucocorticoid with high local activity but much lower systemic availability than prednisolone. Topical formulations have long been licensed for use in asthma and rhinitis. Here we discuss a new orally active controlled-release preparation of budesonide (Entocort CR - Astra) formulated specifically for treating patients with Crohn\\\\\\\'s disease affecting the ileum and/or ascending colon. The manufacturer claims that the preparation \\\\\\\"targets the ileum and ileocaecal area, achieving rapid results equivalent to prednisolone\\\\\\\" with a \\\\\\\"low level of systemic steroid side effects\\\\\\\".
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